1985 - 1988 , 理学博士 , 北京大学生化系 1982 - 1985 , 理学硕士 , 中国农业大学生化系。
1977 - 1982 , 学习 , 农学系 , 黑龙江农垦大学 ,工农兵学员。
工作经历2000 - now , 教授 , 北京大学生命科学学院。
1999 - 2000 , 负责人 , 国家人类基因组北方研究中心。
1997 - 1999 , 主任,教授 , 中山大学分子医学研究中心。
1989 - 1997 , 博士后,研究员 , 美国国立健康研究院(NIH)。
顾军 教授
1988 - 1989 , 客座研究人员 , 复旦大学遗传教研室。主讲课程分子生物学研究进展 , 讲课 , 北京大学 , 秋季学期。
分子生物学, 主持 , 北京大学 , 秋季学期。
研究方向1 炎症及炎症相关疾病(心血管,癌症等)的发生发展机制。
2 基因工程及基于生物技术的疾病治疗方法研究。
3 炎症是机体的免疫反应。炎症失控和过度可以损伤机体甚至产生致死,同时炎症又和许多疾病的发生发展关系密切。我们的研究兴趣主要集中在先天免疫的信号通路是如何参与炎症调控的,这些信号通路是如何与炎症相关疾病发生关联的。哪些信号分子和基因可以作为药物靶点。研究和发现这些靶点以及作用这些靶点的内源分子是我们另一研究领域。同时我们在利用现代生物技术发展治疗方法上进行相关研究。
主要贡献Research Description:
1. Cellular signal transduction and apoptosis. We focus on the signal pathways in innate immune system and inflammation related diseases。
2. The cloning and functional study of disease related genes. We are interested in the genes related to aging、inflammation and cancer。
3. Gene medicine and gene therapy. We are developing recombinant protein and peptide against tumor、inflammation and thrombus as well as gene therapy model。
代表性论文:
1.
Wang J, Wu S, Jin X, Li M, Chen S, Teeling JL, Perry VH, Gu J , Retinoic Acid-Inducible Gene-I Mediates Late Phase Induction of TNF- by Lipopolysaccharide , J Immunol , 2008 , Jun 15;180(12):8011-9。⊥11
10⊥
.Yufei Zou, Yahui Chen, Yongqiang Jiang Jin Gao and Jun Gu , Targeting Matrix Metalloproteinases and endothelial cells with a fusion peptide against tumor , Cancer Res , 2007 , 67:7295-7300。⊥11
.He J, Chen S. and Gu J , Identification and characterization of Harobin, a novel fibrino(geno)lytic serine protease from a sea snake (Lapemis hardwickii) , FEBS Lett , 2007 , 581(16):2965-73。
⊥1110⊥
.Ziqiang Yang, Wei Cheng, Lixin Hong, Shengcai Lin, Jiahuai Han, Huamin Zhou and Jun Gu , Adenine nucleotide (ADP/ATP) translocase 3 participates in the tumor necrosis factor-induced apoptosis of MCF-7 cells , Molecular Biology of the Cell , 2007 , 18: 4681-89。⊥11
10⊥
⊥11
. Wei JX, Sun ZG, Chen QL and Gu J. , Serum deprivation induced apoptosis in macrophage is mediated by autocrine secretion of type I IFNs , Apoptosis , 2006 , 11(4):545-54。
7.
Jing Fu, Ziqiang Yang,Jinxue Wei,Jiahuai Han and Jun Gu. , NP60 nuclear protein regulates p38 MAPK activity. , J Cell Sci. , 2006 , 119(Pt 1):115-23。⊥1110⊥
.Fu WX, Wei JX and Gu J. , MEF2C mediates the activation induced cell death (AICD) of macrophage. , Cell Res. , 2006 , 16, 559-565。⊥11.He JY, Deng J, Zheng J and Gu J , A synergistic effect on the production of S-adenosyl-l-methionine in Pichia pastoris by knocking in of S-adenosyl-l-methionine synthase and knocking out of cystathionine-beta synthase , J Biotechnol , 2006 , 126(4), 519-527。
10.
Xue-Dong Wang, Jian-Guo Tang, Xiao-lei Xie, Ji-Chun Yang, Shuai Li, Jian-Guo Ji and Jun Gu , A comprehensive study of optimal conditions for naked plasmid DNA transfer into skeletal muscle by electroporation. , J Gene Med , 2005 , 7:1235-1245。11
.Liu BN, Tang JG, Ji JG, and Gu J , The expression of functional human parathyroid homone in a gene therapy model for osteoporosis , Cell Tissue Res , 2004 , 317, 57-63。12
.Kegang Shang, Xiaoke wang, and Jun Gu , Differentiation of Embryonic Stem Cell to Astrocytes Visualized by Green Fluoresent Protein Fuchou Tang , Cellular and Molecular Neurobiology , 2002 , 22: 95-101。13
.J.Sun, MT,LI, J.Han and J,Gu. , Sensitization of differentiated PC12 cells to apoptpsis by presenilin-2mediated by p38 , Biochem. Biophy. Res. Com. , 2001 , 287; 536-541, 2001。14
.J,Gu et al,in International Human Genome Consortium , Initial sequencing and analysis of the human genome , Nature , 2001 , 409:860-921。15
.W.Zhu, J.S.Downey, J,GU, F.D.Padova, H.Gram and J.Han , Regulation of TNF expression by multiple MAP kinase pathway , J. Immunology , 2000 , 164:6349-6358。